Grant Lab: Computational Biophysics & Bioinformatics

Our research involves the use of computational approaches, based on both biophysics and bioinformatics, to study the structure, function and evolution of key biological macromolecules.

We are particularly interested in nature’s nanomachines: molecular motors and switches, which lie at the heart of important biological processes, from the division and growth of cells to the muscular movement of organisms. A major portion of our research is focused on deciphering how these fascinating proteins work, and how to manipulate them for industrial and medical advantage. Read more →

Our specific areas of expertise include:

Bio3D Logo

Bio3D software for structural bioinformatics

We lead the development of the Bio3D package used by thousands of researchers around the world to investigate protein sequence-structure-function relationships. Learn more about Bio3D →

Group Members


There are lots of opportunities to get involved in our work! In addition to current openings, we are interested in hearing from energetic University of Michigan graduate and undergraduate students who would like to learn more about our research. Prospective postdocs and students should contact Professor Grant directly.

Current Openings →