amd

Conformational Selection & Allostery in Molecular Switches

The critical activating conformational change common to all P-loop NTPases has traditionally been described in terms of an induced-fit model, where the presence or absence of the γ-phosphate of GTP or ATP leads to an instantaneous switch in conformation.

Our atomistic molecular simulations indicate that these enzymes harbor an intrinsic susceptibility to sample multiple conformational states regardless of the bound nucleotide. These results indicate that conformational changes in these enzymes may be best described by a population-shift mechanism rather than by the popular ligand induced-fit on/off switch model. Read More...

Molecular Motors & the Cytoskeleton


We are fascinated by molecular motion, particularly that of nature’s motor proteins: kinesin, myosin and dynein. Together with their cellular highways, microtubules and actin filaments, these proteins drive the beating of sperm, the division of cells and the muscular movement of organisms. Our research is focused on d
eciphering how these mighty molecular motors work, and how to manipulate them for industrial and medical advantage.

A principal aim in the study of molecular motors, is a detailed understanding of how chemical energy, derived from the hydrolysis of ATP, is converted into mechanical energy. Read More...